InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ep300

Summary

InnateDB Protein

IDBP-164784.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Ep300

Protein Name

E1A binding protein p300

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066789

InnateDB Gene

IDBG-164782 (Ep300)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 443 interaction(s) predicted by orthology.

Experimentally validated
Total	96 [view]
Protein-Protein	69 [view]
Protein-DNA	27 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	443 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001085	RNA polymerase II transcription factor binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001159	core promoter proximal region DNA binding
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0003823	antigen binding
GO:0004402	histone acetyltransferase activity
GO:0004468	lysine N-acetyltransferase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016407	acetyltransferase activity
GO:0016746	transferase activity, transferring acyl groups
GO:0019901	protein kinase binding
GO:0031490	chromatin DNA binding
GO:0032403	protein complex binding
GO:0033613	activating transcription factor binding
GO:0035257	nuclear hormone receptor binding
GO:0035259	glucocorticoid receptor binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:0043425	bHLH transcription factor binding
GO:0046332	SMAD binding
GO:0050681	androgen receptor binding
GO:0051019	mitogen-activated protein kinase binding
GO:0051059	NF-kappaB binding
GO:0097157	pre-mRNA intronic binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001666	response to hypoxia
GO:0001756	somitogenesis
GO:0001889	liver development
GO:0001934	positive regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006475	internal protein amino acid acetylation
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0007507	heart development
GO:0007519	skeletal muscle tissue development
GO:0007623	circadian rhythm
GO:0009749	response to glucose
GO:0009887	organ morphogenesis
GO:0010560	positive regulation of glycoprotein biosynthetic process
GO:0010628	positive regulation of gene expression
GO:0010942	positive regulation of cell death
GO:0014070	response to organic cyclic compound
GO:0014737	positive regulation of muscle atrophy
GO:0016573	histone acetylation
GO:0018076	N-terminal peptidyl-lysine acetylation
GO:0018393	internal peptidyl-lysine acetylation
GO:0030154	cell differentiation
GO:0030307	positive regulation of cell growth
GO:0030324	lung development
GO:0031324	negative regulation of cellular metabolic process
GO:0031325	positive regulation of cellular metabolic process
GO:0032025	response to cobalt ion
GO:0032092	positive regulation of protein binding
GO:0032526	response to retinoic acid
GO:0032967	positive regulation of collagen biosynthetic process
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0034612	response to tumor necrosis factor
GO:0035690	cellular response to drug
GO:0035984	cellular response to trichostatin A
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388	positive regulation of DNA binding
GO:0043491	protein kinase B signaling
GO:0043627	response to estrogen
GO:0043923	positive regulation by host of viral transcription
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0043969	histone H2B acetylation
GO:0045471	response to ethanol
GO:0045727	positive regulation of translation
GO:0045773	positive regulation of axon extension
GO:0045793	positive regulation of cell size
GO:0045862	positive regulation of proteolysis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048565	digestive tract development
GO:0050714	positive regulation of protein secretion
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051216	cartilage development
GO:0051592	response to calcium ion
GO:0060177	regulation of angiotensin metabolic process
GO:0060298	positive regulation of sarcomere organization
GO:0060548	negative regulation of cell death
GO:0060765	regulation of androgen receptor signaling pathway
GO:0065004	protein-DNA complex assembly
GO:0070301	cellular response to hydrogen peroxide
GO:0070542	response to fatty acid
GO:0071236	cellular response to antibiotic
GO:0071300	cellular response to retinoic acid
GO:0071320	cellular response to cAMP
GO:0071333	cellular response to glucose stimulus
GO:0071389	cellular response to mineralocorticoid stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071548	response to dexamethasone
GO:0071549	cellular response to dexamethasone stimulus
GO:0090043	regulation of tubulin deacetylation
GO:1901985	positive regulation of protein acetylation
GO:1990090	cellular response to nerve growth factor stimulus
GO:2000629	negative regulation of miRNA metabolic process

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0032993	protein-DNA complex

Protein Structure and Domains

PDB ID

MGI:1276116

InterPro

IPR000197 Zinc finger, TAZ-type
IPR000433 Zinc finger, ZZ-type
IPR001487 Bromodomain
IPR003101 Coactivator CBP, KIX domain
IPR009110 Nuclear receptor coactivator, interlocking
IPR010303 Domain of unknown function DUF902, CREBbp
IPR011011 Zinc finger, FYVE/PHD-type
IPR013178 Histone H3-K56 acetyltransferase, RTT109
IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlocking

PFAM