Version 5.4
Homo sapiens Protein: PKP3
Summary
InnateDB Protein IDBP-16384.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKP3
Protein Name plakophilin 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000331678
InnateDB Gene IDBG-16380 (PKP3)
Protein Structure
UniProt Annotation
Function May play a role in junctional plaques.
Subcellular Localization Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes.
Disease Associations
Tissue Specificity Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors. {ECO:0000269PubMed:24178805}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0002159 desmosome assembly
GO:0016337 single organismal cell-cell adhesion
GO:0090002 establishment of protein localization to plasma membrane
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0030057 desmosome
Protein Structure and Domains
PDB ID
InterPro IPR000225 Armadillo
IPR016024 Armadillo-type fold
PFAM PF00514
PRINTS
PIRSF
SMART SM00185
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y446
PhosphoSite PhosphoSite-Q9Y446
TrEMBL E9PRW6
UniProt Splice Variant
Entrez Gene 11187
UniGene Hs.534395
RefSeq NP_009114
HUGO HGNC:9025
OMIM 605561
CCDS CCDS7695
HPRD 05711
IMGT
EMBL AC138230 AF053719 AK223511 BC000081 DA439471 FN421477 Z98265
GenPept AAF23050 AAH00081 BAD97231 CAB44310 CAZ65731

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca