InnateDB Protein
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IDBP-162888.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ngdn
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Protein Name
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neuroguidin, EIF4E binding protein
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Synonyms
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1500001L15Rik; neuroguidin; Ngd;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000022815
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InnateDB Gene
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IDBG-162886 (Ngdn)
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Protein Structure
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Function |
Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner. {ECO:0000269PubMed:16705177}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:16705177}. Nucleus, nucleolus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:16705177}. Cell projection, axon {ECO:0000269PubMed:16705177}. Cell projection, dendrite {ECO:0000269PubMed:16705177}. Cell projection, filopodium {ECO:0000269PubMed:16705177}. Note=Translocated from nucleolus to nuclear foci in response to UV damage (By similarity). Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in testis, ovary, spleen, kidney, hippocampus and cerebellum (at protein level). Expressed in testis, ovary, spleen, kidney, brain. {ECO:0000269PubMed:16705177}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1916216
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InterPro |
IPR007146
Sas10/Utp3/C1D
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PFAM |
PF04000
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9DB96
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PhosphoSite |
PhosphoSite-Q9DB96
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TrEMBL |
B0LAE8
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UniProt Splice Variant |
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Entrez Gene |
68966
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UniGene |
Mm.21214
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RefSeq |
NP_081166
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MGI ID |
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MGI Symbol |
Ngdn
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OMIM |
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CCDS |
CCDS36928
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HPRD |
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IMGT |
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EMBL |
AK005098
BC023770
BC052790
EF437387
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GenPept |
AAH23770
AAH52790
ABS83542
BAB23816
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