InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd80

Summary

InnateDB Protein

IDBP-160290.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd80

Protein Name

CD80 antigen

Synonyms

B71; Cd28l; Ly-53; Ly53; MIC17; TSA1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097404

InnateDB Gene

IDBG-160288 (Cd80)

Protein Structure

UniProt Annotation

Function

Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed on activated B-cells, gamma interferon stimulated monocytes and non-circulating B-cell malignancies.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0031295	T cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0045087	innate immune response
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation

Cellular Component

GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:101775

InterPro

IPR003597 Immunoglobulin C1-set
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07654
PF07686
PF08205

PRINTS

PIRSF

SMART

SM00407
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q00609