InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP2CB

Summary

InnateDB Protein

IDBP-15990.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP2CB

Protein Name

protein phosphatase 2, catalytic subunit, beta isozyme

Synonyms

PP2Abeta; PP2CB;

Species

Homo sapiens

Ensembl Protein

ENSP00000221138

InnateDB Gene

IDBG-15988 (PPP2CB)

Protein Structure

UniProt Annotation

Function

PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. {ECO:0000269PubMed:2555176}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16541025}. Nucleus {ECO:0000269PubMed:16541025}. Chromosome, centromere {ECO:0000269PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	123 [view]
Protein-Protein	123 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008637	apoptotic mitochondrial changes
GO:0010468	regulation of gene expression
GO:0034976	response to endoplasmic reticulum stress
GO:0042542	response to hydrogen peroxide
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0046580	negative regulation of Ras protein signal transduction
GO:0046677	response to antibiotic

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0000775	chromosome, centromeric region
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PR00114

PIRSF

SMART

SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt