InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wfs1

Summary

InnateDB Protein

IDBP-158642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wfs1

Protein Name

Wolfram syndrome 1 homolog (human)

Synonyms

AI481085; wolframin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048053

InnateDB Gene

IDBG-158640 (Wfs1)

Protein Structure

UniProt Annotation

Function

Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in the developing lens. {ECO:0000269PubMed:23531866}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005516	calmodulin binding
GO:0031625	ubiquitin protein ligase binding
GO:0033613	activating transcription factor binding
GO:0048306	calcium-dependent protein binding
GO:0051117	ATPase binding

Biological Process

GO:0001822	kidney development
GO:0003091	renal water homeostasis
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031398	positive regulation of protein ubiquitination
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0034976	response to endoplasmic reticulum stress
GO:0042048	olfactory behavior
GO:0042593	glucose homeostasis
GO:0043069	negative regulation of programmed cell death
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0045862	positive regulation of proteolysis
GO:0045927	positive regulation of growth
GO:0050821	protein stabilization
GO:0050877	neurological system process
GO:0051247	positive regulation of protein metabolic process
GO:0051726	regulation of cell cycle
GO:0051928	positive regulation of calcium ion transport
GO:0055074	calcium ion homeostasis
GO:0070845	polyubiquitinated misfolded protein transport
GO:1902236	negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000675	negative regulation of type B pancreatic cell apoptotic process