Homo sapiens Protein: DUSP4
Summary
InnateDB Protein IDBP-15551.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP4
Protein Name dual specificity phosphatase 4
Synonyms HVH2; MKP-2; MKP2; TYP;
Species Homo sapiens
Ensembl Protein ENSP00000240100
InnateDB Gene IDBG-15549 (DUSP4)
Protein Structure
UniProt Annotation
Function Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0008330 protein tyrosine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process
GO:0000165 MAPK cascade
GO:0000188 inactivation of MAPK activity
GO:0001706 endoderm formation
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001763 Rhodanese-like domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PF00782
PF00581
PRINTS PR00700
PR01764
PIRSF PIRSF000939
SMART SM00194
SM00450
SM00404
SM00195
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13115
PhosphoSite PhosphoSite-Q13115
TrEMBL
UniProt Splice Variant
Entrez Gene 1846
UniGene Hs.619323
RefSeq NP_001385
HUGO HGNC:3070
OMIM 602747
CCDS CCDS6072
HPRD 04123
IMGT
EMBL AC084262 AK314820 AL137704 BC002671 BC014565 CH471080 U21108 U48807
GenPept AAA85119 AAC50452 AAH02671 AAH14565 BAG37342 EAW63481 EAW63482 EAW63483 EAW63484