Version 5.4
Mus musculus Protein: Txnl1
Summary
InnateDB Protein IDBP-153376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Txnl1
Protein Name thioredoxin-like 1
Synonyms 32kDa; TRP32; Txnl;
Species Mus musculus
Ensembl Protein ENSMUSP00000025476
InnateDB Gene IDBG-153374 (Txnl1)
Protein Structure
UniProt Annotation
Function Active thioredoxin with a redox potential of about -250 mV. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=At least 85% of the cellular TXNL1 is proteasome-associated. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015035 protein disulfide oxidoreductase activity
GO:0015036 disulfide oxidoreductase activity
Biological Process
GO:0006662 glycerol ether metabolic process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1860078
InterPro IPR008979 Galactose-binding domain-like
IPR010400 PITH domain
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF06201
PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CDN6
PhosphoSite PhosphoSite-Q8CDN6
TrEMBL
UniProt Splice Variant
Entrez Gene 53382
UniGene Mm.431551
RefSeq NP_058072
MGI ID
MGI Symbol Txnl1
OMIM
CCDS CCDS29297
HPRD
IMGT
EMBL AF052660 AK029807 AK150326 AK167954 AK168712 BC061123
GenPept AAC40183 AAH61123 BAC26626 BAE29469 BAE39954 BAE40554

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca