InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fermt2

Summary

InnateDB Protein

IDBP-153346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fermt2

Protein Name

fermitin family homolog 2 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044554

InnateDB Gene

IDBG-153344 (Fermt2)

Protein Structure

UniProt Annotation

Function

Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269PubMed:18174465, ECO:0000269PubMed:18483218, ECO:0000269PubMed:21378273}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, I band. Cell surface. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in adult heart muscle (at protein level). Detected in heart, skeletal muscle and testis. {ECO:0000269PubMed:18174465}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0008360	regulation of cell shape
GO:0016055	Wnt signaling pathway
GO:0033622	integrin activation
GO:0034446	substrate adhesion-dependent cell spreading
GO:0048041	focal adhesion assembly
GO:0072657	protein localization to membrane

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0009986	cell surface
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031258	lamellipodium membrane
GO:0031674	I band
GO:0031941	filamentous actin

Protein Structure and Domains

PDB ID

MGI:2385001

InterPro

IPR001849 Pleckstrin homology domain
IPR018979 FERM, N-terminal
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR029071 Ubiquitin-related domain

PFAM

PF00169
PF09379
PF00373

PRINTS

PIRSF

SMART

SM00233
SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CIB5