InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSNK1G2

Summary

InnateDB Protein

IDBP-15176.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSNK1G2

Protein Name

casein kinase 1, gamma 2

Synonyms

CK1g2;

Species

Homo sapiens

Ensembl Protein

ENSP00000255641

InnateDB Gene

IDBG-15174 (CSNK1G2)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. {ECO:0000269PubMed:15077195, ECO:0000269PubMed:15342122, ECO:0000269PubMed:15917222, ECO:0000269PubMed:18794808, ECO:0000269PubMed:19005213}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15077195}.

Disease Associations

Tissue Specificity

Testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0001948	glycoprotein binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042277	peptide binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006665	sphingolipid metabolic process
GO:0007165	signal transduction
GO:0016055	Wnt signaling pathway
GO:0030148	sphingolipid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR022247 Casein kinase 1 gamma C-terminal

PFAM

PF00069
PF07714
PF12605

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt