InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mthfd1

Summary

InnateDB Protein

IDBP-150378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mthfd1

Protein Name

methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase

Synonyms

Dcs; E430024A07Rik; Mthfd;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021443

InnateDB Gene

IDBG-150376 (Mthfd1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004329	formate-tetrahydrofolate ligase activity
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524	ATP binding

Biological Process

GO:0000105	histidine biosynthetic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0009086	methionine biosynthetic process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0035999	tetrahydrofolate interconversion
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1342005

InterPro

IPR000559 Formate-tetrahydrofolate ligase, FTHFS
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01268
PF00763
PF02882

PRINTS

PR00085

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q922D8