Mus musculus Protein: Ppp2cb
Summary
InnateDB Protein IDBP-147602.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp2cb
Protein Name protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Synonyms AI115466; D8Ertd766e; PP2Ac;
Species Mus musculus
Ensembl Protein ENSMUSP00000009774
InnateDB Gene IDBG-147600 (Ppp2cb)
Protein Structure
UniProt Annotation
Function PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
Subcellular Localization Cytoplasm. Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 88 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0008637 apoptotic mitochondrial changes
GO:0010468 regulation of gene expression
GO:0034976 response to endoplasmic reticulum stress
GO:0042542 response to hydrogen peroxide
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0046677 response to antibiotic
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0000775 chromosome, centromeric region
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1321161
InterPro IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like
PFAM PF00149
PRINTS PR00114
PIRSF
SMART SM00156
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P62715
PhosphoSite PhosphoSite-P62715
TrEMBL
UniProt Splice Variant
Entrez Gene 19053
UniGene Mm.288765
RefSeq NP_059070
MGI ID
MGI Symbol Ppp2cb
OMIM
CCDS CCDS22233
HPRD
IMGT
EMBL BC058582 Z67746
GenPept AAH58582 CAA91559