InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRM7

Summary

InnateDB Protein

IDBP-14580.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRM7

Protein Name

glutamate receptor, metabotropic 7

Synonyms

GLUR7; GPRC1G; MGLU7; MGLUR7; PPP1R87;

Species

Homo sapiens

Ensembl Protein

ENSP00000373986

InnateDB Gene

IDBG-14568 (GRM7)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269PubMed:9473604}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. {ECO:0000269PubMed:12052533, ECO:0000269PubMed:8840028}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001642	group III metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005246	calcium channel regulator activity
GO:0005509	calcium ion binding
GO:0008066	glutamate receptor activity
GO:0010855	adenylate cyclase inhibitor activity
GO:0016595	glutamate binding
GO:0030165	PDZ domain binding
GO:0070905	serine binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007605	sensory perception of sound
GO:0007608	sensory perception of smell
GO:0014050	negative regulation of glutamate secretion
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0031279	regulation of cyclase activity
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005938	cell cortex
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0032279	asymmetric synapse
GO:0042734	presynaptic membrane
GO:0043198	dendritic shaft
GO:0043235	receptor complex
GO:0045211	postsynaptic membrane
GO:0048786	presynaptic active zone

Protein Structure and Domains

PDB ID

InterPro

IPR000162 GPCR, family 3, metabotropic glutamate receptor
IPR000337 GPCR, family 3
IPR001786 GPCR, family 3, metabotropic glutamate receptor 4
IPR001828 Extracellular ligand-binding receptor
IPR001883 GPCR, family 3, metabotropic glutamate receptor 7
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003

PRINTS

PR00593
PR00248
PR01054
PR01057

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14831