InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trio

Summary

InnateDB Protein

IDBP-131601.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trio

Protein Name

triple functional domain (PTPRF interacting)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087714

InnateDB Gene

IDBG-131599 (Trio)

Protein Structure

UniProt Annotation

Function

Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16943433}. Note=Isoform 2 localizes to early endosomes.

Disease Associations

Tissue Specificity

Widespread in the brain, with more intense signals in the hippocampus, olfactory bulb, cortical layers and cerebellum. Isoform 2 is predominantly expressed in Purkinje neurons of brain. {ECO:0000269PubMed:16943433}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding

Biological Process

GO:0006468	protein phosphorylation
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1927230

InterPro

IPR000219 Dbl homology (DH) domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001251 CRAL-TRIO domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR002017 Spectrin repeat
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR018159 Spectrin/alpha-actinin
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM