InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfp191

Summary

InnateDB Protein

IDBP-131423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp191

Protein Name

zinc finger protein 191

Synonyms

3526401F17Rik; 5033419P20Rik; AI480505; AI642085; AL024422; KOX17; ZF-12; Znf191; Znf24; Znp191;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064637

InnateDB Gene

IDBG-131421 (Zfp191)

Protein Structure

UniProt Annotation

Function

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro. {ECO:0000269PubMed:19544452, ECO:0000269PubMed:20080941}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00187, ECO:0000269PubMed:20080941}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in heart, brain, liver, skeletal muscle, kidney and testis and very low levels in spleen and lung. {ECO:0000269PubMed:10542327, ECO:0000269PubMed:20080941}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0042552	myelination
GO:0045892	negative regulation of transcription, DNA-templated