InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CFD

Summary

InnateDB Protein

IDBP-13131.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CFD

Protein Name

complement factor D (adipsin)

Synonyms

ADIPSIN; ADN; DF; PFD;

Species

Homo sapiens

Ensembl Protein

ENSP00000332139

InnateDB Gene

IDBG-13129 (CFD)

Protein Structure

UniProt Annotation

Function

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

Subcellular Localization

Secreted.

Disease Associations

Complement factor D deficiency (CFDD) [MIM:613912]: An immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. {ECO:0000269PubMed:16527897}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity

Biological Process

GO:0002576	platelet degranulation
GO:0006508	proteolysis
GO:0006956	complement activation
GO:0006957	complement activation, alternative pathway
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0045087	innate immune response

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel

PFAM

PF00089
PF09342

PRINTS

PR00722

PIRSF

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt