InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIGB

Summary

InnateDB Protein

IDBP-13019.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIGB

Protein Name

phosphatidylinositol glycan anchor biosynthesis, class B

Synonyms

GPI-MT-III; PIG-B;

Species

Homo sapiens

Ensembl Protein

ENSP00000164305

InnateDB Gene

IDBG-13017 (PIGB)

Protein Structure

UniProt Annotation

Function

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly. {ECO:0000269PubMed:8861954}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:8861954}; Multi-pass membrane protein {ECO:0000269PubMed:8861954}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000030	mannosyltransferase activity
GO:0016757	transferase activity, transferring glycosyl groups

Biological Process

GO:0006501	C-terminal protein lipidation
GO:0006506	GPI anchor biosynthetic process
GO:0008152	metabolic process
GO:0016254	preassembly of GPI anchor in ER membrane
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0097502	mannosylation