InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCKAR

Summary

InnateDB Protein

IDBP-12725.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCKAR

Protein Name

cholecystokinin A receptor

Synonyms

CCK-A; CCK1-R; CCK1R; CCKRA;

Species

Homo sapiens

Ensembl Protein

ENSP00000295589

InnateDB Gene

IDBG-12723 (CCKAR)

Protein Structure

UniProt Annotation

Function

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004951	cholecystokinin receptor activity

Biological Process

GO:0001764	neuron migration
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007409	axonogenesis
GO:0007584	response to nutrient
GO:0007586	digestion
GO:0007631	feeding behavior
GO:0030900	forebrain development
GO:0038188	cholecystokinin signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000314 Gastrin receptor
IPR000596 Cholecystokinin receptor type A
IPR000611 Neuropeptide Y receptor family
IPR009126 Cholecystokinin receptor
IPR015276 Cholecystokinin A receptor, N-terminal
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF09193
PF10320
PF10328

PRINTS

PR00237
PR00527
PR00524
PR01012
PR01822

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32238