Version 5.4
Homo sapiens Protein: RNF126
Summary
InnateDB Protein IDBP-12658.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF126
Protein Name ring finger protein 126
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000292363
InnateDB Gene IDBG-12656 (RNF126)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase. By ubiquitinating CDKN1A/p21 and targeting it for proteasomal degradation, may promote cell proliferation. {ECO:0000269PubMed:23026136}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Highly expressed in liver and testis. {ECO:0000269PubMed:23026136}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BV68
PhosphoSite PhosphoSite-Q9BV68
TrEMBL Q9NPN4
UniProt Splice Variant
Entrez Gene 55658
UniGene Hs.69554
RefSeq NP_919442
HUGO HGNC:21151
OMIM 615177
CCDS CCDS12039
HPRD 11501
IMGT
EMBL AC004449 AK000559 AL360265 BC001442 BC025374 CH471242
GenPept AAC06149 AAH01442 AAH25374 BAA91254 CAB96178 EAW61168 EAW61173

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca