Homo sapiens Protein: PKDREJ
Summary
InnateDB Protein IDBP-11890.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKDREJ
Protein Name polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000253255
InnateDB Gene IDBG-11888 (PKDREJ)
Protein Structure
UniProt Annotation
Function May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Exclusively expressed in testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0007218 neuropeptide signaling pathway
GO:0007340 acrosome reaction
GO:0050982 detection of mechanical stimulus
GO:0055085 transmembrane transport
GO:0060046 regulation of acrosome reaction
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000203 GPS motif
IPR001024 PLAT/LH2 domain
IPR002859 PKD/REJ-like protein
IPR003915 Polycystic kidney disease type 2 protein
IPR005821 Ion transport domain
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014010 Egg jelly receptor, REJ-like
PFAM PF01825
PF01477
PF02010
PF00520
PF08016
PRINTS PR01433
PIRSF
SMART SM00303
SM00308
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NTG1
PhosphoSite PhosphoSite-Q9NTG1
TrEMBL A6MW40
UniProt Splice Variant
Entrez Gene 10343
UniGene Hs.609094
RefSeq NP_006062
HUGO HGNC:9015
OMIM 604670
CCDS CCDS14073
HPRD 05239
IMGT
EMBL AF116458 AL031034 AL078611 AL137288 CH471138 EF517278 Z93024
GenPept AAD18021 ABR22603 CAB70680 CAI18792 CAI18795 EAW73411