InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPM7

Summary

InnateDB Protein

IDBP-11809.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPM7

Protein Name

transient receptor potential cation channel, subfamily M, member 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000320239

InnateDB Gene

IDBG-11807 (TRPM7)

Protein Structure

UniProt Annotation

Function

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). {ECO:0000269PubMed:12887921, ECO:0000269PubMed:15485879, ECO:0000269PubMed:24316671}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1) [MIM:105500]: A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004674	protein serine/threonine kinase activity
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017022	myosin binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0016340	calcium-dependent cell-matrix adhesion
GO:0031032	actomyosin structure organization
GO:0034220	ion transmembrane transport
GO:0046777	protein autophosphorylation
GO:0055085	transmembrane transport
GO:0070266	necroptotic process
GO:0070588	calcium ion transmembrane transport