InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRKCH

Summary

InnateDB Gene

IDBG-8479.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKCH

Gene Name

protein kinase C, eta

Synonyms

nPKC-eta; PKC-L; PKCL; PRKCL

Species

Homo sapiens

Ensembl Gene

ENSG00000027075

Encoded Proteins

IDBP-8481

protein kinase C, eta

IDBP-587032

protein kinase C, eta

IDBP-591163

protein kinase C, eta

IDBP-601240

protein kinase C, eta

IDBP-588235

protein kinase C, eta

IDBP-594781

protein kinase C, eta

IDBP-592598

protein kinase C, eta

IDBP-585012

protein kinase C, eta

IDBP-594933

protein kinase C, eta

IDBP-595832

protein kinase C, eta

IDBP-603499

protein kinase C, eta

IDBP-584795

protein kinase C, eta

IDBP-585113

protein kinase C, eta

IDBP-586908

protein kinase C, eta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:61187559-61550976

Strand

Forward strand

Band

q23.1

Transcripts

ENST00000332981	ENSP00000329127
ENST00000555185	ENSP00000451871
ENST00000557294	ENSP00000452129
ENST00000556778	ENSP00000452055
ENST00000555542	ENSP00000451789
ENST00000555906	ENSP00000451205
ENST00000554835
ENST00000555082	ENSP00000450981
ENST00000552875
ENST00000553830	ENSP00000452588
ENST00000553831	ENSP00000450959
ENST00000553726	ENSP00000451793
ENST00000553265	ENSP00000451933
ENST00000556164	ENSP00000452330
ENST00000557585	ENSP00000451930
ENST00000557473	ENSP00000452528
ENST00000553889
ENST00000557559
ENST00000555604
ENST00000555233
ENST00000536400
ENST00000555628
ENST00000555110
ENST00000555382
ENST00000557599
ENST00000553846
ENST00000556245

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004699	calcium-independent protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017160	Ral GTPase binding
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0030168	platelet activation
GO:0034351	negative regulation of glial cell apoptotic process
GO:0035556	intracellular signal transduction
GO:0045618	positive regulation of keratinocyte differentiation
GO:0050861	positive regulation of B cell receptor signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060252	positive regulation of glial cell proliferation
GO:0070528	protein kinase C signaling
GO:2000810	regulation of tight junction assembly