Homo sapiens Gene: PRKCH
Summary
InnateDB Gene IDBG-8479.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKCH
Gene Name protein kinase C, eta
Synonyms nPKC-eta; PKC-L; PKCL; PRKCL;
Species Homo sapiens
Ensembl Gene ENSG00000027075
Encoded Proteins
protein kinase C, eta
protein kinase C, eta
protein kinase C, eta
protein kinase C, eta
protein kinase C, eta
protein kinase C, eta
protein kinase C, eta
protein kinase C, eta
protein kinase C, eta
protein kinase C, eta
protein kinase C, eta
protein kinase C, eta
protein kinase C, eta
protein kinase C, eta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:61187559-61550976
Strand Forward strand
Band q23.1
Transcripts
ENST00000332981 ENSP00000329127
ENST00000555185 ENSP00000451871
ENST00000557294 ENSP00000452129
ENST00000556778 ENSP00000452055
ENST00000555542 ENSP00000451789
ENST00000555906 ENSP00000451205
ENST00000554835
ENST00000555082 ENSP00000450981
ENST00000552875
ENST00000553830 ENSP00000452588
ENST00000553831 ENSP00000450959
ENST00000553726 ENSP00000451793
ENST00000553265 ENSP00000451933
ENST00000556164 ENSP00000452330
ENST00000557585 ENSP00000451930
ENST00000557473 ENSP00000452528
ENST00000553889
ENST00000557559
ENST00000555604
ENST00000555233
ENST00000536400
ENST00000555628
ENST00000555110
ENST00000555382
ENST00000557599
ENST00000553846
ENST00000556245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004699 calcium-independent protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017160 Ral GTPase binding
GO:0019899 enzyme binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0030168 platelet activation
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035556 intracellular signal transduction
GO:0045618 positive regulation of keratinocyte differentiation
GO:0050861 positive regulation of B cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060252 positive regulation of glial cell proliferation
GO:0070528 protein kinase C signaling
GO:2000810 regulation of tight junction assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Wnt pathway
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (z) signalling events pathway
Effects of PIP2 hydrolysis pathway
Hemostasis pathway
KEGG
Vascular smooth muscle contraction pathway
Tight junction pathway
INOH
GPCR signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
Keratinocyte differentiation [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL G3V5F8
UniProt Splice Variant
Entrez Gene 5583
UniGene Hs.333907 Hs.630857 Hs.713372
RefSeq NM_006255
HUGO HGNC:9403
OMIM 605437
CCDS CCDS9752
HPRD 05669
IMGT
EMBL AL138996 AL355916 AL359220
GenPept
RNA Seq Atlas 5583