Version 5.4
Homo sapiens Gene: BLK
Summary
InnateDB Gene IDBG-7345.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BLK
Gene Name B lymphoid tyrosine kinase
Synonyms MODY11
Species Homo sapiens
Ensembl Gene ENSG00000136573
Encoded Proteins
IDBP-7349
B lymphoid tyrosine kinase
IDBP-596338
B lymphoid tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:11494001-11564604
Strand Forward strand
Band p23.1
Transcripts
ENST00000259089 ENSP00000259089
ENST00000525389
ENST00000529894 ENSP00000433663
ENST00000533828
ENST00000526778
ENST00000526097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 20 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0032024 positive regulation of insulin secretion
GO:0035556 intracellular signal transduction
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014453
View Gene Order
ENSBTAG00000005049
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P51451
TrEMBL E9PJX5
UniProt Splice Variant
Entrez Gene 640
UniGene
RefSeq NM_001715 XM_005272390 XM_006716250 XM_006716251
HUGO HGNC:1057
OMIM 191305
CCDS CCDS5982
HPRD
IMGT
EMBL AC022239 AF131216 AK313751 BC007371 BC032413 CH471157 S76617 Z33998
GenPept AAB33265 AAH07371 AAH32413 BAG36491 CAA83965 EAW65617
RNA Seq Atlas 640

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca