Homo sapiens Gene: MAEA | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-6622.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | MAEA | ||||||||||||||||||
Gene Name | macrophage erythroblast attacher | ||||||||||||||||||
Synonyms | EMLP; EMP; GID9; HLC-10; PIG5 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000090316 | ||||||||||||||||||
Encoded Proteins |
macrophage erythroblast attacher
macrophage erythroblast attacher
macrophage erythroblast attacher
macrophage erythroblast attacher
macrophage erythroblast attacher
macrophage erythroblast attacher
macrophage erythroblast attacher
macrophage erythroblast attacher
macrophage erythroblast attacher
macrophage erythroblast attacher
macrophage erythroblast attacher
macrophage erythroblast attacher
macrophage erythroblast attacher
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. This protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Two immunologically related isoforms of erythroblast macrophage protein with apparent molecular weights of 33 kD and 36 kD were detected in macrophage membranes; this gene encodes the larger isoform. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 4:1289851-1340147 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | p16.3 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.139896 Hs.735185 | ||||||||||||||||||
RefSeq | NM_001017405 NM_001297431 NM_001297432 NM_001297433 NM_005882 XM_005272243 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS33936 CCDS33937 CCDS75090 | ||||||||||||||||||
HPRD | 08427 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||