Homo sapiens Gene: PATZ1
Summary
InnateDB Gene IDBG-4572.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PATZ1
Gene Name POZ (BTB) and AT hook containing zinc finger 1
Synonyms dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; ZSG;
Species Homo sapiens
Ensembl Gene ENSG00000100105
Encoded Proteins
POZ (BTB) and AT hook containing zinc finger 1
POZ (BTB) and AT hook containing zinc finger 1
POZ (BTB) and AT hook containing zinc finger 1
POZ (BTB) and AT hook containing zinc finger 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:31325804-31346232
Strand Reverse strand
Band q12.2
Transcripts
ENST00000351933 ENSP00000337520
ENST00000266269 ENSP00000266269
ENST00000215919 ENSP00000215919
ENST00000405309 ENSP00000384173
ENST00000494109
ENST00000465287
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007283 spermatogenesis
GO:0008584 male gonad development
GO:0010468 regulation of gene expression
GO:0030217 T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.581096 Hs.731398
RefSeq NM_014323 NM_032050 NM_032051 NM_032052
HUGO
OMIM
CCDS CCDS13894 CCDS13895 CCDS13896 CCDS46691
HPRD 05522
IMGT
EMBL
GenPept
RNA Seq Atlas