Homo sapiens Gene: MOCOS
Summary
InnateDB Gene IDBG-2601.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MOCOS
Gene Name molybdenum cofactor sulfurase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000075643
Encoded Proteins
molybdenum cofactor sulfurase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH; MIM 607633) and aldehyde oxidase (AOX1; MIM 602841), which is required for their enzymatic activities (Ichida et al., 2001 [PubMed 11302742]).[supplied by OMIM, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:36187519-36272157
Strand Forward strand
Band q12.2
Transcripts
ENST00000261326 ENSP00000261326
ENST00000588132
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008265 Mo-molybdopterin cofactor sulfurase activity
GO:0016740 transferase activity
GO:0016829 lyase activity
GO:0030151 molybdenum ion binding
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006777 Mo-molybdopterin cofactor biosynthetic process
GO:0008152 metabolic process
GO:0032324 molybdopterin cofactor biosynthetic process
GO:0043545 molybdopterin cofactor metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Defective HLCS causes multiple carboxylase deficiency pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Metabolism of water-soluble vitamins and cofactors pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Defective CD320 causes methylmalonic aciduria pathway
Defects in cobalamin (B12) metabolism pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Defects in biotin (Btn) metabolism pathway
Defective BTD causes biotidinase deficiency pathway
Defective GIF causes intrinsic factor deficiency pathway
Defects in vitamin and cofactor metabolism pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Molybdenum cofactor biosynthesis pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Metabolism pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Disease pathway
Metabolism of vitamins and cofactors pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.354068 Hs.405028 Hs.737129
RefSeq NM_017947
HUGO
OMIM
CCDS CCDS11919
HPRD 17585
IMGT
EMBL
GenPept
RNA Seq Atlas