Version 5.4
Homo sapiens Gene: MAPRE2
Summary
InnateDB Gene IDBG-2390.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPRE2
Gene Name microtubule-associated protein, RP/EB family, member 2
Synonyms EB1; EB2; RP1
Species Homo sapiens
Ensembl Gene ENSG00000166974
Encoded Proteins
IDBP-2392
microtubule-associated protein, RP/EB family, member 2
IDBP-367439
microtubule-associated protein, RP/EB family, member 2
IDBP-367442
microtubule-associated protein, RP/EB family, member 2
IDBP-599864
microtubule-associated protein, RP/EB family, member 2
IDBP-725995
IDBP-725597
IDBP-726144
IDBP-728022
IDBP-725908
IDBP-727202
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:34976928-35143470
Strand Forward strand
Band q12.1
Transcripts
ENST00000300249 ENSP00000300249
ENST00000413393 ENSP00000396074
ENST00000436190 ENSP00000407723
ENST00000538170 ENSP00000446343
ENST00000585592
ENST00000591734 ENSP00000468216
ENST00000587359 ENSP00000466871
ENST00000589699 ENSP00000464921
ENST00000588349 ENSP00000468904
ENST00000588910 ENSP00000468588
ENST00000589180 ENSP00000465939
ENST00000590793
ENST00000588085
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0007165 signal transduction
GO:0008283 cell proliferation
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0035371 microtubule plus-end
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024277
View Gene Order
ENSBTAG00000007520
Not yet available
Cross-References
SwissProt
TrEMBL K7ENB3 K7ERD8 M0QX52
UniProt Splice Variant
Entrez Gene 10982
UniGene Hs.532824 Hs.643657 Hs.692866 Hs.731983
RefSeq NM_001143826 NM_001143827 NM_001256420 NM_014268 XM_006722375
HUGO HGNC:6891
OMIM 605789
CCDS CCDS11910 CCDS45850 CCDS45851 CCDS58619
HPRD 16157
IMGT
EMBL AC009277 AC015967
GenPept
RNA Seq Atlas 10982

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca