Homo sapiens Gene: XAF1
Summary
InnateDB Gene IDBG-22619.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XAF1
Gene Name XIAP associated factor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132530
Encoded Proteins
XIAP associated factor 1
XIAP associated factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:6755447-6775647
Strand Forward strand
Band p13.1
Transcripts
ENST00000361842 ENSP00000354822
ENST00000346752 ENSP00000341029
ENST00000575267
ENST00000572107
ENST00000574907 ENSP00000460315
ENST00000575369 ENSP00000461750
ENST00000573760
ENST00000576459
ENST00000571217 ENSP00000459543
ENST00000572495
ENST00000574962 ENSP00000458229
ENST00000573518
ENST00000576724 ENSP00000458321
ENST00000576341
ENST00000575147 ENSP00000460632
ENST00000571673 ENSP00000461196
ENST00000574394 ENSP00000460373
ENST00000571135 ENSP00000461635
ENST00000572546 ENSP00000461698
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006915 apoptotic process
GO:0019221 cytokine-mediated signaling pathway
GO:0031333 negative regulation of protein complex assembly
GO:0035456 response to interferon-beta
GO:0060337 type I interferon signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q6GPH4
TrEMBL
UniProt Splice Variant
Entrez Gene 54739
UniGene
RefSeq NM_017523 NM_199139 XM_005256708 XM_006721550
HUGO HGNC:30932
OMIM 606717
CCDS CCDS11080 CCDS11081
HPRD 06978
IMGT
EMBL AK290276 AK292710 AK292848 BC032776 BC073156 BX649188 CH471108 EF028165 EF028166 X99699
GenPept AAH32776 AAH73156 ABM74556 ABM74557 BAF82965 BAF85399 BAF85537 CAA68030 CAE46206 EAW90288 EAW90289
RNA Seq Atlas 54739