Homo sapiens Gene: RARB
Summary
InnateDB Gene IDBG-22486.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RARB
Gene Name retinoic acid receptor, beta
Synonyms HAP; MCOPS12; NR1B2; RRB2;
Species Homo sapiens
Ensembl Gene ENSG00000077092
Encoded Proteins
retinoic acid receptor, beta
retinoic acid receptor, beta
retinoic acid receptor, beta
retinoic acid receptor, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:25174332-25597932
Strand Forward strand
Band p24.2
Transcripts
ENST00000330688 ENSP00000332296
ENST00000383772 ENSP00000373282
ENST00000437042 ENSP00000398840
ENST00000458646 ENSP00000391391
ENST00000489694
ENST00000480001
ENST00000462272
ENST00000479097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 24 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003708 retinoic acid receptor activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0032403 protein complex binding
GO:0043565 sequence-specific DNA binding
GO:0046965 retinoid X receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001657 ureteric bud development
GO:0002068 glandular epithelial cell development
GO:0003148 outflow tract septum morphogenesis
GO:0003406 retinal pigment epithelium development
GO:0003417 growth plate cartilage development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010467 gene expression
GO:0021756 striatum development
GO:0022008 neurogenesis
GO:0031641 regulation of myelination
GO:0032331 negative regulation of chondrocyte differentiation
GO:0035116 embryonic hindlimb morphogenesis
GO:0035264 multicellular organism growth
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043401 steroid hormone mediated signaling pathway
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048048 embryonic eye morphogenesis
GO:0048384 retinoic acid receptor signaling pathway
GO:0048566 embryonic digestive tract development
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060041 retina development in camera-type eye
GO:0060348 bone development
GO:0061037 negative regulation of cartilage development
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Nuclear Receptor transcription pathway pathway
Generic Transcription Pathway pathway
Gene Expression pathway
KEGG
Pathways in cancer pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P10826
TrEMBL B4DSI3 D6RBI3 F1D8S6 Q5QHG3
UniProt Splice Variant
Entrez Gene 5915
UniGene Hs.654490 Hs.735252
RefSeq NM_000965 NM_001290217 NM_001290266 NM_001290276 NM_001290300 NM_016152
HUGO HGNC:9865
OMIM 180220
CCDS CCDS2642 CCDS46775
HPRD
IMGT
EMBL AC092422 AC093416 AC098477 AC133141 AC133797 AF157483 AK299756 AY501390 BC060794 CH471055 HQ692863 HQ692864 M57445 X04014 X07282 X56849 X77664 Y00291
GenPept AAA58728 AAD45688 AAH60794 AAS85757 ADZ17374 ADZ17375 BAG61645 CAA27637 CAA30262 CAA54740 CAA68398 EAW64354 EAW64355
RNA Seq Atlas 5915