Version 5.4
Homo sapiens Gene: C1QBP
Summary
InnateDB Gene IDBG-21497.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1QBP
Gene Name complement component 1, q subcomponent binding protein
Synonyms gC1Q-R; GC1QBP; gC1qR; HABP1; p32; SF2p32
Species Homo sapiens
Ensembl Gene ENSG00000108561
Encoded Proteins
IDBP-21499
complement component 1, q subcomponent binding protein
IDBP-764373
IDBP-757841
IDBP-764897
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 12574814
Binds proteins involved in complement, coagulation, and kinin systems, as well as viral and bacterial pathogens including S. aureus protein A and when expressed on activated platelets may contribute directly to thrombosis, inflammation and endovascular infections
Entrez Gene
Summary The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:5432777-5448830
Strand Reverse strand
Band p13.2
Transcripts
ENST00000225698 ENSP00000225698
ENST00000573204
ENST00000574444 ENSP00000460308
ENST00000576122 ENSP00000458624
ENST00000573421
ENST00000570805 ENSP00000460638
ENST00000573406
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 164 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 164 [view]
Protein-Protein 164 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001849 complement component C1q binding
GO:0003714 transcription corepressor activity
GO:0003729 mRNA binding
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005540 hyaluronic acid binding
GO:0008134 transcription factor binding
GO:0030984 kininogen binding
GO:0031690 adrenergic receptor binding
GO:0097177 mitochondrial ribosome binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006397 mRNA processing
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0006958 complement activation, classical pathway
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0008380 RNA splicing
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016032 viral process
GO:0030449 regulation of complement activation
GO:0032689 negative regulation of interferon-gamma production
GO:0032695 negative regulation of interleukin-12 production
GO:0039534 negative regulation of MDA-5 signaling pathway
GO:0039536 negative regulation of RIG-I signaling pathway
GO:0042256 mature ribosome assembly
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045785 positive regulation of cell adhesion
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0050687 negative regulation of defense response to virus
GO:0051897 positive regulation of protein kinase B signaling
GO:0070131 positive regulation of mitochondrial translation
GO:0090023 positive regulation of neutrophil chemotaxis
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1901165 positive regulation of trophoblast cell migration
GO:2000510 positive regulation of dendritic cell chemotaxis
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018446
View Gene Order
ENSBTAG00000012739
Not yet available
Pathways
NETPATH
REACTOME
REACT_326
Intrinsic Pathway pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001212
HUGO
OMIM
CCDS CCDS11071
HPRD 03168
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca