Version 5.4
Homo sapiens Gene: ARHGAP17
Summary
InnateDB Gene IDBG-21389.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP17
Gene Name Rho GTPase activating protein 17
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140750
Encoded Proteins
IDBP-21391
Rho GTPase activating protein 17
IDBP-21393
Rho GTPase activating protein 17
IDBP-373258
Rho GTPase activating protein 17
IDBP-745728
IDBP-751927
IDBP-745713
IDBP-751911
IDBP-746057
IDBP-747892
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:24919385-25015666
Strand Reverse strand
Band p12.1
Transcripts
ENST00000289968 ENSP00000289968
ENST00000303665 ENSP00000303130
ENST00000455311 ENSP00000406701
ENST00000575656
ENST00000573703
ENST00000570841
ENST00000571843 ENSP00000461639
ENST00000575447
ENST00000571480 ENSP00000459074
ENST00000571575
ENST00000573765 ENSP00000460985
ENST00000576387
ENST00000575975
ENST00000570320
ENST00000575412
ENST00000572314
ENST00000575283
ENST00000573449 ENSP00000461426
ENST00000571406 ENSP00000460600
ENST00000573625 ENSP00000461411
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030766
View Gene Order
ENSBTAG00000020043
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.373793 Hs.596568
RefSeq NM_001006634 NM_018054 XM_005255413 XM_006721057 XM_006721058 XM_006721059 XM_006721060
HUGO
OMIM
CCDS CCDS32408 CCDS32409
HPRD 12207
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca