Version 5.4
Homo sapiens Gene: STAP1
Summary
InnateDB Gene IDBG-21034.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAP1
Gene Name signal transducing adaptor family member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000035720
Encoded Proteins
IDBP-21036
signal transducing adaptor family member 1
IDBP-237957
signal transducing adaptor family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:67558728-67607337
Strand Forward strand
Band q13.2
Transcripts
ENST00000265404 ENSP00000265404
ENST00000396225 ENSP00000379527
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0061025 membrane fusion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029254
View Gene Order
ENSBTAG00000000962
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
NetPath_12
BCR pathway
REACTOME
KEGG
INOH
PID NCI
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt Q9ULZ2
TrEMBL A0A024RD91
UniProt Splice Variant
Entrez Gene 26228
UniGene Hs.435579
RefSeq XM_006714175 NM_012108
HUGO HGNC:24133
OMIM 604298
CCDS CCDS3515
HPRD 16053
IMGT
EMBL AB023483 AK313676 BC014958 CH471057
GenPept AAH14958 BAA85311 BAG36427 EAX05547 EAX05548
RNA Seq Atlas 26228

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca