Homo sapiens Gene: CCL28
Summary
InnateDB Gene IDBG-19270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL28
Gene Name chemokine (C-C motif) ligand 28
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151882
Encoded Proteins
chemokine (C-C motif) ligand 28
chemokine (C-C motif) ligand 28
chemokine (C-C motif) ligand 28
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:43376645-43412391
Strand Reverse strand
Band p12
Transcripts
ENST00000361115 ENSP00000354416
ENST00000489442 ENSP00000426424
ENST00000513525 ENSP00000422369
ENST00000514421
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007584 response to nutrient
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Not yet available
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
Intestinal immune network for IgA production pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9NRJ3
TrEMBL A0N0Q3 D6RC73
UniProt Splice Variant
Entrez Gene 56477
UniGene Hs.656904
RefSeq NM_148672
HUGO HGNC:17700
OMIM 605240
CCDS CCDS3944
HPRD
IMGT
EMBL AC025457 AF110384 AF220210 AF266504 AK312120 BC062668 BC069532 CH471119 EF064761 HM067700
GenPept AAF87205 AAG16691 AAG43193 AAH62668 AAH69532 ABK41944 ADH95184 BAG35056 EAW56057 EAW56058 EAW56059
RNA Seq Atlas 56477