Version 5.4
Homo sapiens Gene: PAPOLA
Summary
InnateDB Gene IDBG-19245.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAPOLA
Gene Name poly(A) polymerase alpha
Synonyms PAP
Species Homo sapiens
Ensembl Gene ENSG00000090060
Encoded Proteins
IDBP-19247
poly(A) polymerase alpha
IDBP-244523
poly(A) polymerase alpha
IDBP-597603
poly(A) polymerase alpha
IDBP-587100
poly(A) polymerase alpha
IDBP-584004
poly(A) polymerase alpha
IDBP-584259
poly(A) polymerase alpha
IDBP-595529
poly(A) polymerase alpha
IDBP-592953
poly(A) polymerase alpha
IDBP-585889
poly(A) polymerase alpha
IDBP-597862
poly(A) polymerase alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3\'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:96501433-96567111
Strand Forward strand
Band q32.2
Transcripts
ENST00000216277 ENSP00000216277
ENST00000392990 ENSP00000376716
ENST00000554887
ENST00000553357 ENSP00000452578
ENST00000553689 ENSP00000451600
ENST00000557320 ENSP00000450437
ENST00000554130
ENST00000557471 ENSP00000450812
ENST00000556619 ENSP00000451267
ENST00000555626 ENSP00000450534
ENST00000556248
ENST00000557406
ENST00000555224
ENST00000555912
ENST00000553461 ENSP00000450564
ENST00000555131
ENST00000555021
ENST00000554666
ENST00000556787
ENST00000555701
ENST00000556283
ENST00000554135
ENST00000556459 ENSP00000451757
ENST00000553940
ENST00000555508
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein-Protein 39 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004652 polynucleotide adenylyltransferase activity
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
GO:0030145 manganese ion binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0031123 RNA 3'-end processing
GO:0031124 mRNA 3'-end processing
GO:0043631 RNA polyadenylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021111
View Gene Order
ENSBTAG00000004054
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_1096
Processing of Intronless Pre-mRNAs pathway
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1768
Processing of Capped Intronless Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.604266 Hs.717122 Hs.731218
RefSeq NM_001252006 NM_001252007 NM_001293627 NM_001293628 NM_032632 XM_005267281
HUGO
OMIM
CCDS CCDS58334 CCDS58335 CCDS9946
HPRD 10407
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca