InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRKAA1

Summary

InnateDB Gene

IDBG-18226.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKAA1

Gene Name

protein kinase, AMP-activated, alpha 1 catalytic subunit

Synonyms

AMPK; AMPKa1

Species

Homo sapiens

Ensembl Gene

ENSG00000132356

Encoded Proteins

IDBP-18228

protein kinase, AMP-activated, alpha 1 catalytic subunit

IDBP-18232

protein kinase, AMP-activated, alpha 1 catalytic subunit

IDBP-236049

protein kinase, AMP-activated, alpha 1 catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5\'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:40759379-40798374

Strand

Reverse strand

Band

p13.1

Transcripts

ENST00000354209	ENSP00000346148
ENST00000296800	ENSP00000296800
ENST00000397128	ENSP00000380317
ENST00000397006
ENST00000513152
ENST00000505783
ENST00000506652
ENST00000509874
ENST00000511248

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 144 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	144 [view]
Protein-Protein	141 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004679	AMP-activated protein kinase activity
GO:0004691	cAMP-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019900	kinase binding
GO:0035174	histone serine kinase activity
GO:0046872	metal ion binding
GO:0047322	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0050321	tau-protein kinase activity
GO:0050405	[acetyl-CoA carboxylase] kinase activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0001666	response to hypoxia
GO:0006006	glucose metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006633	fatty acid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0006914	autophagy
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008610	lipid biosynthetic process
GO:0009411	response to UV
GO:0009631	cold acclimation
GO:0010332	response to gamma radiation
GO:0010508	positive regulation of autophagy
GO:0010628	positive regulation of gene expression
GO:0014823	response to activity
GO:0016055	Wnt signaling pathway
GO:0019395	fatty acid oxidation
GO:0031000	response to caffeine
GO:0031669	cellular response to nutrient levels
GO:0032007	negative regulation of TOR signaling
GO:0035404	histone-serine phosphorylation
GO:0042149	cellular response to glucose starvation
GO:0042542	response to hydrogen peroxide
GO:0042593	glucose homeostasis
GO:0042752	regulation of circadian rhythm
GO:0043066	negative regulation of apoptotic process
GO:0045542	positive regulation of cholesterol biosynthetic process
GO:0045821	positive regulation of glycolytic process
GO:0046318	negative regulation of glucosylceramide biosynthetic process
GO:0048511	rhythmic process
GO:0050995	negative regulation of lipid catabolic process
GO:0051291	protein heterooligomerization
GO:0055089	fatty acid homeostasis
GO:0060627	regulation of vesicle-mediated transport
GO:0070301	cellular response to hydrogen peroxide
GO:0071361	cellular response to ethanol
GO:0071417	cellular response to organonitrogen compound
GO:0071456	cellular response to hypoxia
GO:1901563	response to camptothecin
GO:2000505	regulation of energy homeostasis
GO:2001274	negative regulation of glucose import in response to insulin stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016324	apical plasma membrane
GO:0031588	AMP-activated protein kinase complex
GO:0043234	protein complex