InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NFIC

Summary

InnateDB Gene

IDBG-17079.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFIC

Gene Name

nuclear factor I/C (CCAAT-binding transcription factor)

Synonyms

CTF; CTF5; NF-I; NFI

Species

Homo sapiens

Ensembl Gene

ENSG00000141905

Encoded Proteins

IDBP-17085

nuclear factor I/C (CCAAT-binding transcription factor)

IDBP-240205

nuclear factor I/C (CCAAT-binding transcription factor)

IDBP-364068

nuclear factor I/C (CCAAT-binding transcription factor)

IDBP-763891

IDBP-762009

IDBP-765136

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:3359563-3469217

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000341919	ENSP00000342194
ENST00000395111	ENSP00000378543
ENST00000443272	ENSP00000396843
ENST00000590282	ENSP00000466647
ENST00000589123	ENSP00000465655
ENST00000589537
ENST00000586919	ENSP00000465177
ENST00000589164
ENST00000588839
ENST00000589969

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001159	core promoter proximal region DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006260	DNA replication
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005730	nucleolus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000055053

View Gene Order

ENSBTAG00000008520

Not yet available

Pathways

NETPATH

REACTOME

REACT_22339

RNA Polymerase III Abortive And Retractive Initiation pathway

REACT_63

RNA Polymerase III Transcription Termination pathway

REACT_1371

RNA Polymerase III Transcription pathway

REACT_21352

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P08651

TrEMBL

UniProt Splice Variant

Entrez Gene

4782

UniGene

Hs.170131 Hs.560695 Hs.569985 Hs.711598

RefSeq

NM_001245002 NM_001245004 NM_001245005 NM_005597 NM_205843

HUGO

HGNC:7786

OMIM

600729

CCDS

CCDS59330 CCDS12107 CCDS45914 CCDS58640 CCDS59331

HPRD

IMGT

EMBL

AC005514 AC005551 AC005778 AK289885 AK297867 AK304816 BC012120 CH471139 X12492 X92857

GenPept

AAC32593 AAC32594 AAC33190 AAC33191 AAC33192 AAC62842 AAH12120 BAF82574 BAH12681 BAH14259 CAA31012 CAA63440 EAW69325 EAW69326

RNA Seq Atlas

4782