InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADAMTS12

Summary

InnateDB Gene

IDBG-14831.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS12

Gene Name

ADAM metallopeptidase with thrombospondin type 1 motif, 12

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000151388

Encoded Proteins

IDBP-14833

ADAM metallopeptidase with thrombospondin type 1 motif, 12

IDBP-473495

ADAM metallopeptidase with thrombospondin type 1 motif, 12

IDBP-479414

ADAM metallopeptidase with thrombospondin type 1 motif, 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:33523535-33892192

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000352040	ENSP00000344847
ENST00000504830	ENSP00000422554
ENST00000504582
ENST00000506952
ENST00000515401	ENSP00000421638
ENST00000509762

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007160	cell-matrix adhesion
GO:0016477	cell migration
GO:0030167	proteoglycan catabolic process
GO:0032331	negative regulation of chondrocyte differentiation
GO:0050727	regulation of inflammatory response
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071773	cellular response to BMP stimulus
GO:1901509	regulation of endothelial tube morphogenesis
GO:1902203	negative regulation of hepatocyte growth factor receptor signaling pathway
GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus
GO:2001113	negative regulation of cellular response to hepatocyte growth factor stimulus

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000047497

View Gene Order

ENSBTAG00000012558

Not yet available

Pathways

NETPATH

REACTOME

REACT_22161

Post-translational protein modification pathway

REACT_200727

O-linked glycosylation pathway

REACT_17015

Metabolism of proteins pathway

REACT_200626

O-glycosylation of TSR domain-containing proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.12680

RefSeq

NM_030955

HUGO

OMIM

CCDS

CCDS34140

HPRD

05862

IMGT

EMBL

GenPept

RNA Seq Atlas