Version 5.4
| Homo sapiens Gene: SEL1L | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-14682.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SEL1L | ||||||||||||||||||
| Gene Name | sel-1 suppressor of lin-12-like (C. elegans) | ||||||||||||||||||
| Synonyms | PRO1063; SEL1-LIKE; SEL1L1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000071537 | ||||||||||||||||||
| Encoded Proteins |
sel-1 suppressor of lin-12-like (C. elegans)
sel-1 suppressor of lin-12-like (C. elegans)
sel-1 suppressor of lin-12-like (C. elegans)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 14:81471549-81533861 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q31.1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Pre-NOTCH Processing in Golgi pathway
Processing-defective Hh variants abrogate ligand secretion pathway
Signaling by Hedgehog pathway
Pre-NOTCH Expression and Processing pathway
Signal Transduction pathway
Hh ligand biogenesis disease pathway
Hedgehog ligand biogenesis pathway
Signaling by NOTCH pathway
Disease pathway
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| KEGG |
Protein processing in endoplasmic reticulum pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9UBV2 | ||||||||||||||||||
| TrEMBL | G3V3B3 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 6400 | ||||||||||||||||||
| UniGene | Hs.181300 Hs.708488 Hs.708669 | ||||||||||||||||||
| RefSeq | NM_001244984 NM_005065 XM_005267988 | ||||||||||||||||||
| HUGO | HGNC:10717 | ||||||||||||||||||
| OMIM | 602329 | ||||||||||||||||||
| CCDS | CCDS58333 CCDS9876 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB020335 AB024763 AF052059 AF157516 AF198631 AF198632 AF198633 AF198634 AF198635 AF198636 AF198637 AF198638 AF198639 AF198640 AF198641 AF198642 AF198643 AF198644 AF198645 AF198646 AF198647 AL121769 AL136039 AY358651 | ||||||||||||||||||
| GenPept | AAF24176 AAF29413 AAL40905 AAQ89014 BAA87904 BAA89204 | ||||||||||||||||||
| RNA Seq Atlas | 6400 | ||||||||||||||||||