InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYO1E

Summary

InnateDB Gene

IDBG-14485.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO1E

Gene Name

myosin IE

Synonyms

FSGS6; HuncM-IC; MYO1C

Species

Homo sapiens

Ensembl Gene

ENSG00000157483

Encoded Proteins

IDBP-14487

myosin IE

IDBP-591222

myosin IE

IDBP-590416

myosin IE

IDBP-587219

myosin IE

IDBP-593999

myosin IE

IDBP-592962

myosin IE

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:59132434-59372900

Strand

Reverse strand

Band

q22.2

Transcripts

ENST00000288235	ENSP00000288235
ENST00000559412	ENSP00000453936
ENST00000559269	ENSP00000453232
ENST00000560749	ENSP00000454113
ENST00000558182
ENST00000560642
ENST00000559489	ENSP00000453178
ENST00000558814
ENST00000558571	ENSP00000453811
ENST00000558646

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0035091	phosphatidylinositol binding
GO:0042623	ATPase activity, coupled
GO:0051015	actin filament binding

Biological Process

GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0003094	glomerular filtration
GO:0006200	ATP catabolic process
GO:0006807	nitrogen compound metabolic process
GO:0006897	endocytosis
GO:0008152	metabolic process
GO:0030048	actin filament-based movement
GO:0030097	hemopoiesis
GO:0032836	glomerular basement membrane development
GO:0035166	post-embryonic hemopoiesis
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0072015	glomerular visceral epithelial cell development

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0015629	actin cytoskeleton
GO:0016459	myosin complex
GO:0045334	clathrin-coated endocytic vesicle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032220

View Gene Order

ENSBTAG00000021538

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.654506

RefSeq

NM_004998

HUGO

OMIM

CCDS

CCDS32254

HPRD

03281

IMGT

EMBL

GenPept

RNA Seq Atlas