Homo sapiens Gene: MYO1E
Summary
InnateDB Gene IDBG-14485.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYO1E
Gene Name myosin IE
Synonyms FSGS6; HuncM-IC; MYO1C;
Species Homo sapiens
Ensembl Gene ENSG00000157483
Encoded Proteins
myosin IE
myosin IE
myosin IE
myosin IE
myosin IE
myosin IE
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:59132434-59372900
Strand Reverse strand
Band q22.2
Transcripts
ENST00000288235 ENSP00000288235
ENST00000559412 ENSP00000453936
ENST00000559269 ENSP00000453232
ENST00000560749 ENSP00000454113
ENST00000558182
ENST00000560642
ENST00000559489 ENSP00000453178
ENST00000558814
ENST00000558571 ENSP00000453811
ENST00000558646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0003774 motor activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0035091 phosphatidylinositol binding
GO:0042623 ATPase activity, coupled
GO:0051015 actin filament binding
Biological Process
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0003094 glomerular filtration
GO:0006200 ATP catabolic process
GO:0006807 nitrogen compound metabolic process
GO:0006897 endocytosis
GO:0008152 metabolic process
GO:0030048 actin filament-based movement
GO:0030097 hemopoiesis
GO:0032836 glomerular basement membrane development
GO:0035166 post-embryonic hemopoiesis
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0072015 glomerular visceral epithelial cell development
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0015629 actin cytoskeleton
GO:0016459 myosin complex
GO:0045334 clathrin-coated endocytic vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 4643
UniGene Hs.654506
RefSeq NM_004998
HUGO HGNC:7599
OMIM 601479
CCDS CCDS32254
HPRD 03281
IMGT
EMBL
GenPept
RNA Seq Atlas 4643