Homo sapiens Gene: RFC1
Summary
InnateDB Gene IDBG-14028.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFC1
Gene Name replication factor C (activator 1) 1, 145kDa
Synonyms A1; MHCBFB; PO-GA; RECC1; RFC; RFC140;
Species Homo sapiens
Ensembl Gene ENSG00000035928
Encoded Proteins
replication factor C (activator 1) 1, 145kDa
replication factor C (activator 1) 1, 145kDa
replication factor C (activator 1) 1, 145kDa
replication factor C (activator 1) 1, 145kDa
replication factor C (activator 1) 1, 145kDa
replication factor C (activator 1) 1, 145kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3\' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:39287456-39366375
Strand Reverse strand
Band p14
Transcripts
ENST00000381897 ENSP00000371321
ENST00000349703 ENSP00000261424
ENST00000418436
ENST00000510783
ENST00000502991
ENST00000504974
ENST00000514572 ENSP00000424713
ENST00000505077
ENST00000504554 ENSP00000422129
ENST00000502706
ENST00000509084
ENST00000512881
ENST00000512726
ENST00000504849
ENST00000512275 ENSP00000422475
ENST00000503784 ENSP00000422740
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 59 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008047 enzyme activator activity
GO:0019904 protein domain specific binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006351 transcription, DNA-templated
GO:0007004 telomere maintenance via telomerase
GO:0032201 telomere maintenance via semi-conservative replication
GO:0043085 positive regulation of catalytic activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0030054 cell junction
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DNA Replication pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
Polymerase switching on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Transcription-coupled NER (TC-NER) pathway
Synthesis of DNA pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
S Phase pathway
Chromosome Maintenance pathway
Polymerase switching pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
Cell Cycle pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Leading Strand Synthesis pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Nucleotide Excision Repair pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
DNA Repair pathway
KEGG
DNA replication pathway
Nucleotide excision repair pathway
Mismatch repair pathway
INOH
PID BIOCARTA
Alk in cardiac myocytes [Biocarta view]
PID NCI
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.507475 Hs.595029
RefSeq NM_001204747 NM_002913
HUGO
OMIM
CCDS CCDS3450 CCDS56329
HPRD 00024
IMGT
EMBL
GenPept
RNA Seq Atlas