Homo sapiens Gene: PTK2B
Summary
InnateDB Gene IDBG-13899.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTK2B
Gene Name PTK2B protein tyrosine kinase 2 beta
Synonyms CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2; RAFTK;
Species Homo sapiens
Ensembl Gene ENSG00000120899
Encoded Proteins
PTK2B protein tyrosine kinase 2 beta
PTK2B protein tyrosine kinase 2 beta
PTK2B protein tyrosine kinase 2 beta
PTK2B protein tyrosine kinase 2 beta
PTK2B protein tyrosine kinase 2 beta
PTK2B protein tyrosine kinase 2 beta
PTK2B protein tyrosine kinase 2 beta
PTK2B protein tyrosine kinase 2 beta
PTK2B protein tyrosine kinase 2 beta
PTK2B protein tyrosine kinase 2 beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PTK2B mediates the JAK-dependent activation of MAPK and STAT1 in interferon (IFN)-gamma, but not IFN-alpha signalling.
PTK2B amplifies epidermal growth factor receptor (EGFR) and SRC-induced STAT3 activation, implicating PTK2B activation as a potential co-mediator in triggering STAT3-induced oncogenesis.
Entrez Gene
Summary This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:27311482-27459391
Strand Forward strand
Band p21.2
Transcripts
ENST00000346049 ENSP00000332816
ENST00000397501 ENSP00000380638
ENST00000397497 ENSP00000380634
ENST00000420218 ENSP00000391995
ENST00000412793 ENSP00000416174
ENST00000519650
ENST00000522338 ENSP00000429694
ENST00000521164 ENSP00000430404
ENST00000522517 ENSP00000428271
ENST00000496920
ENST00000517339 ENSP00000427931
ENST00000521000
ENST00000519512 ENSP00000428837
ENST00000461615
ENST00000495097
ENST00000482543
ENST00000522245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 97 [view]
Protein-Protein 96 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0032403 protein complex binding
GO:0043423 3-phosphoinositide-dependent protein kinase binding
Biological Process
GO:0000165 MAPK cascade
GO:0000302 response to reactive oxygen species
GO:0001525 angiogenesis
GO:0001556 oocyte maturation
GO:0001666 response to hypoxia
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002040 sprouting angiogenesis
GO:0002315 marginal zone B cell differentiation
GO:0006461 protein complex assembly
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006950 response to stress
GO:0006968 cellular defense response
GO:0006970 response to osmotic stress
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007229 integrin-mediated signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0009612 response to mechanical stimulus
GO:0009725 response to hormone
GO:0009749 response to glucose
GO:0010226 response to lithium ion
GO:0010243 response to organonitrogen compound
GO:0010595 positive regulation of endothelial cell migration
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0010758 regulation of macrophage chemotaxis
GO:0010976 positive regulation of neuron projection development
GO:0014009 glial cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030155 regulation of cell adhesion
GO:0030279 negative regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030502 negative regulation of bone mineralization
GO:0030838 positive regulation of actin filament polymerization
GO:0031175 neuron projection development
GO:0032863 activation of Rac GTPase activity
GO:0032960 regulation of inositol trisphosphate biosynthetic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035902 response to immobilization stress
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042976 activation of Janus kinase activity
GO:0043066 negative regulation of apoptotic process
GO:0043149 stress fiber assembly
GO:0043267 negative regulation of potassium ion transport
GO:0043507 positive regulation of JUN kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043534 blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045453 bone resorption
GO:0045471 response to ethanol
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045727 positive regulation of translation
GO:0045860 positive regulation of protein kinase activity
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048041 focal adhesion assembly
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051591 response to cAMP
GO:0051592 response to calcium ion
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060291 long-term synaptic potentiation
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071300 cellular response to retinoic acid
GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000114 regulation of establishment of cell polarity
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
GO:2000538 positive regulation of B cell chemotaxis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0014069 postsynaptic density
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030027 lamellipodium
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0097440 apical dendrite
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TCR pathway
BCR pathway
IL2 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
Oncostatin_M pathway
REACTOME
Cell-Cell communication pathway
Signaling by VEGF pathway
Cytokine Signaling in Immune system pathway
Signal regulatory protein (SIRP) family interactions pathway
Signal Transduction pathway
Immune System pathway
Interleukin-2 signaling pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
KEGG
Calcium signaling pathway pathway
Chemokine signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Leukocyte transendothelial migration pathway
GnRH signaling pathway pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Role of nicotinic acetylcholine receptors in the regulation of apoptosis [Biocarta view]
Thrombin signaling and protease-activated receptors [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Calcium signaling by hbx of hepatitis b virus [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
Il-7 signal transduction [Biocarta view]
PID NCI
Alpha-synuclein signaling
LPA receptor mediated events
IL2-mediated signaling events
CXCR4-mediated signaling events
Coregulation of Androgen receptor activity
Integrins in angiogenesis
FGF signaling pathway
Endothelins
Signaling events mediated by VEGFR1 and VEGFR2
Alpha4 beta1 integrin signaling events
Osteopontin-mediated events
Cross-References
SwissProt Q14289
TrEMBL C9JHV9 E5RHL2 E5RJ77 E5RK84 E9PBI4
UniProt Splice Variant
Entrez Gene 2185
UniGene Hs.491322 Hs.601924
RefSeq NM_004103 NM_173174 NM_173175 NM_173176 XM_005273447
HUGO HGNC:9612
OMIM 601212
CCDS CCDS6057 CCDS6058
HPRD
IMGT
EMBL AC010856 AC124649 AF311103 BC036651 BC042599 CH471080 D45853 L49207 S80542 U33284 U43522
GenPept AAB35701 AAB47217 AAC05330 AAC50203 AAH36651 AAH42599 BAA08289 EAW63553 EAW63555 EAW63556
RNA Seq Atlas 2185