Homo sapiens Gene: VSX2
Summary
InnateDB Gene IDBG-11935.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VSX2
Gene Name visual system homeobox 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119614
Encoded Proteins
visual system homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:74239472-74262738
Strand Forward strand
Band q24.3
Transcripts
ENST00000261980 ENSP00000261980
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007601 visual perception
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0043010 camera-type eye development
GO:0045165 cell fate commitment
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050896 response to stimulus
GO:0060040 retinal bipolar neuron differentiation
GO:0060042 retina morphogenesis in camera-type eye
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt P58304
TrEMBL
UniProt Splice Variant
Entrez Gene 338917
UniGene Hs.449771
RefSeq NM_182894
HUGO HGNC:1975
OMIM 142993
CCDS CCDS9827
HPRD 08852
IMGT
EMBL AC005519 AC006349 AY336059 BC128153 CH471061
GenPept AAI28154 AAQ01593 EAW81164
RNA Seq Atlas 338917