Version 5.4
Homo sapiens Gene: MAEA
Summary
InnateDB Gene IDBG-6622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAEA
Gene Name macrophage erythroblast attacher
Synonyms EMLP; EMP; GID9; HLC-10; PIG5
Species Homo sapiens
Ensembl Gene ENSG00000090316
Encoded Proteins
IDBP-6624
macrophage erythroblast attacher
IDBP-6626
macrophage erythroblast attacher
IDBP-476755
macrophage erythroblast attacher
IDBP-481686
macrophage erythroblast attacher
IDBP-482463
macrophage erythroblast attacher
IDBP-482367
macrophage erythroblast attacher
IDBP-478606
macrophage erythroblast attacher
IDBP-476470
macrophage erythroblast attacher
IDBP-477339
macrophage erythroblast attacher
IDBP-483169
macrophage erythroblast attacher
IDBP-482082
macrophage erythroblast attacher
IDBP-479598
macrophage erythroblast attacher
IDBP-482062
macrophage erythroblast attacher
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. This protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Two immunologically related isoforms of erythroblast macrophage protein with apparent molecular weights of 33 kD and 36 kD were detected in macrophage membranes; this gene encodes the larger isoform. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:1289851-1340147
Strand Forward strand
Band p16.3
Transcripts
ENST00000303400 ENSP00000302830
ENST00000264750 ENSP00000264750
ENST00000505177 ENSP00000422215
ENST00000513301 ENSP00000423056
ENST00000512308 ENSP00000422235
ENST00000503653 ENSP00000421644
ENST00000509254 ENSP00000426326
ENST00000502558 ENSP00000426903
ENST00000514708 ENSP00000427512
ENST00000508634
ENST00000503693
ENST00000509531 ENSP00000426966
ENST00000510862
ENST00000510794 ENSP00000426807
ENST00000512842 ENSP00000427460
ENST00000505839 ENSP00000424436
ENST00000512289
ENST00000506530
ENST00000503162
ENST00000515766
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 13 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007346 regulation of mitotic cell cycle
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0043249 erythrocyte maturation
GO:0048821 erythrocyte development
GO:0048822 enucleate erythrocyte development
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005819 spindle
GO:0005826 actomyosin contractile ring
GO:0005856 cytoskeleton
GO:0005887 integral component of plasma membrane
GO:0015629 actin cytoskeleton
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079562
View Gene Order
ENSBTAG00000012575
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.139896 Hs.735185
RefSeq NM_001017405 NM_001297431 NM_001297432 NM_001297433 NM_005882 XM_005272243
HUGO
OMIM
CCDS CCDS33936 CCDS33937 CCDS75090
HPRD 08427
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca