InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.76048

Summary

InnateDB Gene

IDBG-641741.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.76048

Gene Name

cyclic AMP-dependent transcription factor ATF-4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017462

Encoded Proteins

IDBP-694134

cyclic AMP-dependent transcription factor ATF-4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22496230

[Homo sapiens] Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded protein response (Demonstrated in mice)

PMID 22496230

[Mus musculus] Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded protein response

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128272:
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:111462845-111464936

Strand

Forward strand

Band

Transcripts

ENSBTAT00000023213

ENSBTAP00000023213

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006094	gluconeogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0034976	response to endoplasmic reticulum stress
GO:0043525	positive regulation of neuron apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress