Bos taurus Gene: FKBP4
InnateDB Gene IDBG-640857.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FKBP4
Gene Name peptidyl-prolyl cis-trans isomerase FKBP4
Synonyms FKBP-4; FKBP-52
Species Bos taurus
Ensembl Gene ENSBTAG00000007605
Encoded Proteins
peptidyl-prolyl cis-trans isomerase FKBP4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004478:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:107445596-107453517
Strand Reverse strand
ENSBTAT00000009998 ENSBTAP00000009998
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005528 FK506 binding
GO:0031072 heat shock protein binding
GO:0035259 glucocorticoid receptor binding
GO:0044822 poly(A) RNA binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0006463 steroid hormone receptor complex assembly
GO:0007566 embryo implantation
GO:0030521 androgen receptor signaling pathway
GO:0030850 prostate gland development
GO:0031503 protein complex localization
GO:0046661 male sex differentiation
GO:0048608 reproductive structure development
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0070062 extracellular vesicular exosome
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
AndrogenReceptor pathway
Cellular responses to stress pathway
Attenuation phase pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
Cellular responses to stress pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
Attenuation phase pathway
Coregulation of Androgen receptor activity
Glucocorticoid receptor regulatory network
UniProt Splice Variant
Entrez Gene 508535
UniGene Bt.4797
RefSeq NM_001034322
EMBL DAAA02014573 DAAA02014574
RNA Seq Atlas 508535