Version 5.4
Bos taurus Gene: SYN3
Summary
InnateDB Gene IDBG-637818.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYN3
Gene Name synapsin-3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020636
Encoded Proteins
IDBP-689855
synapsin III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185666:
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in multiple splice variants that encode different isoforms. [provided by RefSeq, Oct 2008]
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene\'s localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in multiple splice variants that encode different isoforms. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:71475847-71926718
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027501 ENSBTAP00000027501
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005524 ATP binding
Biological Process
GO:0007269 neurotransmitter secretion
GO:0008152 metabolic process
Cellular Component
GO:0008021 synaptic vesicle
GO:0030672 synaptic vesicle membrane
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000185666
View Gene Order
ENSMUSG00000059602
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15293
Dopamine Neurotransmitter Release Cycle pathway
REACT_15425
Serotonin Neurotransmitter Release Cycle pathway
REACT_13685
Neuronal System pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MCX8
UniProt Splice Variant
Entrez Gene 100138309
UniGene Bt.61438
RefSeq NM_001191357 XM_005206768 XM_005206770
HUGO HGNC:11496
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02013759
GenPept
RNA Seq Atlas 100138309

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca