Version 5.4
Homo sapiens Gene: EIF3D
Summary
InnateDB Gene IDBG-5983.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3D
Gene Name eukaryotic translation initiation factor 3, subunit D
Synonyms eIF3-p66; eIF3-zeta; EIF3S7
Species Homo sapiens
Ensembl Gene ENSG00000100353
Encoded Proteins
IDBP-5985
eukaryotic translation initiation factor 3, subunit D
IDBP-294004
eukaryotic translation initiation factor 3, subunit D
IDBP-293991
eukaryotic translation initiation factor 3, subunit D
IDBP-374849
eukaryotic translation initiation factor 3, subunit D
IDBP-374853
eukaryotic translation initiation factor 3, subunit D
IDBP-374858
eukaryotic translation initiation factor 3, subunit D
IDBP-374863
eukaryotic translation initiation factor 3, subunit D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:36510850-36529436
Strand Reverse strand
Band q12.3
Transcripts
ENST00000216190 ENSP00000216190
ENST00000405442 ENSP00000385812
ENST00000402116 ENSP00000385212
ENST00000426531
ENST00000458572 ENSP00000391061
ENST00000455547 ENSP00000390438
ENST00000457241 ENSP00000403584
ENST00000432675 ENSP00000402192
ENST00000478547
ENST00000462641
ENST00000462794
ENST00000496875
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 83 [view]
Protein-Protein 82 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0001732 formation of translation initiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016020 membrane
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016554
View Gene Order
ENSBTAG00000001988
Not yet available
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.55682
RefSeq NM_003753
HUGO
OMIM
CCDS CCDS13930
HPRD 04888
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca