InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD80

Summary

InnateDB Gene

IDBG-51287.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD80

Gene Name

CD80 molecule

Synonyms

B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7

Species

Homo sapiens

Ensembl Gene

ENSG00000121594

Encoded Proteins

IDBP-51289

CD80 molecule

IDBP-51291

CD80 molecule

IDBP-482870

CD80 molecule

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:119524293-119559602

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000264246	ENSP00000264246
ENST00000383669	ENSP00000373165
ENST00000478182	ENSP00000418364
ENST00000463729

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015026	coreceptor activity

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0016032	viral process
GO:0031295	T cell costimulation
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0042110	T cell activation
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response
GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045627	positive regulation of T-helper 1 cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation