Mus musculus Gene: Trpm7
Summary
InnateDB Gene IDBG-204376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trpm7
Gene Name transient receptor potential cation channel, subfamily M, member 7
Synonyms 2310022G15Rik; 4833414K03Rik; 5033407O22Rik; CHAK; CHAK1; Ltpr7; LTrpC-7; Ltrpc7; TRPPLIK;
Species Mus musculus
Ensembl Gene ENSMUSG00000027365
Encoded Proteins
transient receptor potential cation channel, subfamily M, member 7
transient receptor potential cation channel, subfamily M, member 7
transient receptor potential cation channel, subfamily M, member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092439:
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:126791565-126876230
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000103224 ENSMUSP00000099513
ENSMUST00000028843 ENSMUSP00000028843
ENSMUST00000127277
ENSMUST00000155675
ENSMUST00000136964 ENSMUSP00000119232
ENSMUST00000135733
ENSMUST00000125327
ENSMUST00000142334
ENSMUST00000132003
ENSMUST00000134408
ENSMUST00000152615
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004674 protein serine/threonine kinase activity
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017022 myosin binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0016340 calcium-dependent cell-matrix adhesion
GO:0031032 actomyosin structure organization
GO:0046777 protein autophosphorylation
GO:0055085 transmembrane transport
GO:0070266 necroptotic process
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0001726 ruffle
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Stimuli-sensing channels pathway
Ion channel transport pathway
Transmembrane transport of small molecules pathway
TRP channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
TRP channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.244705 Mm.406396 Mm.407674 Mm.416047
RefSeq NM_001164325 NM_021450 XM_006499965
OMIM
CCDS CCDS16689 CCDS50700
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas