Homo sapiens Gene: RPS6KA5
InnateDB Gene IDBG-16084.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPS6KA5
Gene Name ribosomal protein S6 kinase, 90kDa, polypeptide 5
Synonyms MSK1; MSPK1; RLPK
Species Homo sapiens
Ensembl Gene ENSG00000100784
Encoded Proteins
ribosomal protein S6 kinase, 90kDa, polypeptide 5
ribosomal protein S6 kinase, 90kDa, polypeptide 5
ribosomal protein S6 kinase, 90kDa, polypeptide 5
ribosomal protein S6 kinase, 90kDa, polypeptide 5
ribosomal protein S6 kinase, 90kDa, polypeptide 5
ribosomal protein S6 kinase, 90kDa, polypeptide 5
ribosomal protein S6 kinase, 90kDa, polypeptide 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
RPS6KA5 negatively regulates TLR-pathway driven inflammation by preventing the binding of phosphorylated transcription factors CREB and ATF1 to IL10 and DUSP1 promoters.
RPS6KA5 regulates the transcription of IL1RA in response to TLR activation in macrophages.
Paramyxoviruses trigger the DNA-damage response, a pathway required for RPS6KA5 activation of phospho Ser 276 RELA formation to trigger the IRF7-DDX58 amplification loop necessary for mucosal interferon production.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:90847862-91060636
Strand Reverse strand
Band q32.11
ENST00000261991 ENSP00000261991
ENST00000418736 ENSP00000402787
ENST00000536315 ENSP00000442803
ENST00000556178 ENSP00000451305
ENST00000554206 ENSP00000450591
ENST00000556594 ENSP00000451736
ENST00000614987 ENSP00000479667
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
Experimentally validated
Total 80 [view]
Protein-Protein 72 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0001818 negative regulation of cytokine production
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007411 axon guidance
GO:0009103 lipopolysaccharide biosynthetic process
GO:0016572 histone phosphorylation
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033129 positive regulation of histone phosphorylation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035066 positive regulation of histone acetylation
GO:0035556 intracellular signal transduction
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0043987 histone H3-S10 phosphorylation
GO:0043988 histone H3-S28 phosphorylation
GO:0043990 histone H2A-S1 phosphorylation
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0070498 interleukin-1-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0016020 membrane
No orthologs found for this gene
EGFR1 pathway
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
ERK/MAPK targets pathway
CREB phosphorylation pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Recycling pathway of L1 pathway
L1CAM interactions pathway
NCAM signaling for neurite out-growth pathway
Developmental Biology pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Axon guidance pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
Activated TLR4 signalling pathway
Nuclear Events (kinase and transcription factor activation) pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
MAPK signaling pathway pathway
Bladder cancer pathway
Neurotrophin signaling pathway pathway
Trk receptor signaling mediated by the MAPK pathway
LPA4-mediated signaling events
UniProt Splice Variant
Entrez Gene 9252
UniGene Hs.733807
RefSeq NM_004755 NM_182398
OMIM 603607
HPRD 06789
EMBL AL121784 AL133454 AL159191
RNA Seq Atlas 9252